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Pediatric Pulmonology 46:131–138 (2011)
Do New Zealand Children With Non-Cystic Fibrosis Bronchiectasis Show Disease Progression? Karen A. Munro, FRACP, Peter W. Reed, DPhil, Helen Joyce, MBChB, David Perry, FRANZCR, Jacob Twiss, FRACP, Catherine A. Byrnes, MD, FRACP, GCCE, and Elizabeth A. Edwards, PhD, FRACP* Summary. Background: There is minimal literature available on the long-term outcome of pediatric non-cystic fibrosis (CF) bronchiectasis. Aim: To document 5-year outcomes of children with chest computerized tomography (CT) scan diagnosed bronchiectasis from a tertiary New Zealand (NZ) respiratory clinic. Methods: Review of a clinical database identified 91 children. Demographics, clinical data, lung function, chest X-ray (CXR), sputum, presumed etiology, admission data, and the NZ deprivation index (NZDep) were collected. Univariate and multivariate regression were used to correlate clinical findings with lung function data and CXR scores using the Brasfield Scoring System. Results: Of the 91 children, 53 (59%) were Pacific Island, 22 (24%) Maori, 14 (15%) European, and 2 (2%) Other. The median follow-up period was 6.7 years (range 5.0–15.3 years) and median age at diagnosis was 7.3 years (range 11 months–16 years). Lung function data (n ¼ 64) showed a mean decline of 1.6% predicted/year. In 30 children lung function declined (mean FEV1 4.4% predicted/year, range 1–17%), remained stable in 13 and improved in 21 children (mean FEV1 of þ3% predicted/year, range 1–15%). Reduced lung function was associated with male gender, chronic Haemophilus influenzae infection, longevity of disease, and Maori and Pacific Island ethnicity. There was a significant correlation with FEV1 and CXR score at beginning (n ¼ 47, r ¼ 0.45, P ¼ 0.001) and end (n ¼ 26, r ¼ 0.59, P ¼ 0.002) of the follow-up period. The only variable consistently related to CXR score was chronic Haemophilus influenzae infection occurring in 27 (30%) (r2 ¼ 0.52, P ¼ <0.0001). Only four children were chronically infected with Pseudomonas species. Six children died. Conclusion: In our experience despite management in a tertiary multidisciplinary bronchiectasis clinic, progression of lung disease continues in a group of children and young adults. Pediatr Pulmonol. 2011; 46:131–138. ß 2011 Wiley-Liss, Inc. Key words: ethnicity; outcome; lung function; radiology; colonization. Funding source: Starship Foundation Fellowship.
In New Zealand (NZ), the incidence of diagnosis of pediatric non-cystic fibrosis (CF) bronchiectasis has been described as the equivalent of 1 in 1,700 births, twice the incidence of CF disease.1 The ‘‘incidence’’ of bronchiectasis referred to is the incidence of bronchiectasis diagnosis, rather than disease in the population as, unlike CF, bronchiectasis is not screened for but presents when symptoms are sufficient to warrant a visit to primary care, complex enough to warrant referral to specialty care and severe enough to warrant radiographic evaluation. This is 7 times higher than the reported diagnosis incidence rate in Finland, and 18 times higher than the United Kingdom (UK), the only countries to publish specific rates.2–4 Since the first published review of pediatric bronchiectasis in Auckland NZ,5 between 2000 and 2008 the number of children with bronchiectasis under active review has increased 280% (60–170). This could be due to increased recognition or a true increase in diagnosis of disease. In 1994 bronchiectasis was reported to be the seventh highest cause of death in adult Pacific women,6 and since ß 2011 Wiley-Liss, Inc.
then hospital admission rates have been climbing (Fig. 1).7 Cohort studies from the 1940s and 1950s report mortality rates of 3–5% over 10- to 12-year follow-up periods.8,9 Contemporary cohort studies, that also include children, report a much lower mortality rate of 0–1%.10,11 Indeed, case reports have described resolution and/or improvement in this previously supposed irreversible disease.10,12,13 Pediatric specialist respiratory centers outside NZ have reported short-term outcome data,14,15 Department of Paediatrics, University of Auckland & Starship Children’s Hospital, Auckland, New Zealand *Correspondence to: Elizabeth A. Edwards, PhD, FRACP, Department of Respiratory Medicine, Starship Children’s Hospital, Private Bag 92024, Auckland 1142, New Zealand. E-mail: [email protected] Received 23 November 2009; Revised 20 April 2010; Accepted 31 May 2010. DOI 10.1002/ppul.21331 Published online in Wiley Online Library (wileyonlinelibrary.com).
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service. The endpoints measured were lung function, CXR score, and clinical features of disease severity. METHODS Study Population
Fig. 1. Hospital admissions (1990–2007) and deaths (1990– 2005) due to bronchiectasis in New Zealand children and young people 0–24 years. (Figure provided by Dr Elizabeth Craig, NZ Child and Youth Epidemiology Service 2008. Source: Numerators: National Minimum Dataset and Mortality Collection; Denominator: Census. Note: Mortality data unavailable for 2006–2007.)
but otherwise there is limited longer term outcome data since Field’s work more than 30 years ago.16 Disease progression monitoring using standard parameters (lung function testing, radiology, sputum) has long become usual practice with CF. The first study, published in 1966 to use lung function tests (LFTs) as a measure of bronchiectasis disease progression, found no change with age.17 In 1981 Ellis published results of long-term followup (mean duration 14 years) on 116 adults with bronchiectasis.18 Compared to time of diagnosis, of the 94 survivors, 30% were symptomatically better and only 11% were symptomatically worse. The decline in forced expiratory volume in 1 sec (FEV1) was no greater than seen in normal adults for 80% of the cohort.18 More recently, follow-up data from King et al.19 found that adult patients had persistent symptoms of dyspnea and sputum volume which were worse on follow-up and an excess loss of FEV1 at an average of 49 ml/year (>1% predicted/ year). Other adult data have also shown a mean decline of 3.8% predicted/year but with 25% of the cohort having a much higher decline of >15% predicted/year.20 Similarly in children we have previously shown over the short term (<5 years) a decline in lung function of 1.9% predicted/year.21 In contrast, a recent study of 59 children, mean age 8.2 years, had no change in their forced vital capacity (FVC) (slope 0.21) and FEV1 z scores (slope 0.19) over 2 years.14 Better knowledge of progression is needed for more accurate clinical and prognostic evaluation and to determine appropriate intervention trial outcome measures. The aim of this study was to document outcomes for NZ children and young people with bronchiectasis following at least 5 years of management by a tertiary respiratory Pediatric Pulmonology
Data on children on the computerized bronchiectasis database5,22 at the Starship Children’s Health, Auckland, New Zealand was retrospectively reviewed. The database was established in 1998 and recorded diagnoses from 1991. All children had high-resolution computerized tomography (HRCT) scan diagnosed bronchiectasis and cases identified had been followed for at least 5 years (December 31, 2006). They had undergone a series of investigations to exclude CF and identify the presumed etiology for the bronchiectasis. The data fields were determined at establishment of the database, and where data were available was collected systematically. The data on the individual child were revised when needed at the clinic reviews—most particularly being checked at an ‘‘annual review’’ visit. When possible, data were also collected on those who had transitioned to adult care or had moved within NZ by sending out questionnaires to their current physicians. Data Collected
Demographics, growth (height, weight, body mass index (BMI)), sputum analysis, presumed etiology, and admission data were collected. Children were defined as being chronically infected with a particular organism if they had a positive sputum or bronchoalveolar lavage (BAL) culture on three or more occasions each at least 1 month apart over a 12-month period. Children able to participate had lung function testing carried out at each clinic or inpatient stay by one of two pediatric respiratory technologists performed on a system 62000 Autobox DL Plethysmograph (Sensormedics Corporation, Yorba Linda, CA) according to American Thoracic Society criteria.23 FVC and FEV1 were collected. The Polgar reference equation was used to determine percent predicted as this covered the entire age range.24 Only children who had more than one LFT at least 12 months apart were included in the final analysis and the ‘‘best’’ annual (individuals best spirometric result for each calendar year) was used. Asthma was diagnosed with at least a 15% improvement in FEV1 post-bronchodilator.25 Chest X-rays (CXRs) were evaluated by pediatric radiologists (HJ and DP), blinded to clinical data, at the beginning and end of the follow-up period and scored using the Brasfield score.26 The growth parameters used were those recorded with lung function data at diagnosis and end of follow-up period. The NZ index of deprivation score for each child was noted at the beginning (NZDep96) and end (NZDep2001) of the follow-up
Outcome of NZ Non-Cystic Fibrosis Bronchiectasis 27
period. This has a range from 1 (10% least deprived in NZ) to 10 (10% most deprived in NZ) and is determined by address using a mesh block of 100 persons where possible and combining the following variable in decreasing weight—income, employment, communication, transport, support, qualifications, living space, home ownership. Management
Each child has a named lead consultant and previously described investigation and management strategies with 3–6 monthly clinic follow-up.28–30 Statistical Analysis
Statistical analyses were undertaken with JMP software (SAS Institute, Inc., Cary, NC). Univariate comparisons of variables between children were undertaken with Fisher’s Exact Test. The growth parameters were presented as z scores for height, weight, BMI, and change over time (www.cdc.gov/growthcharts/zscore.htm). Differences in lung function at diagnosis, between subgroups and correlations to clinical findings were investigated by univariate one-way ANOVA and linear regression. Changes in lung function over time were determined by univariate linear regression on a per patient basis (thus correcting for the different number and time periods of observations between patients), and differences between subgroups and correlations to clinical findings investigated by one-way ANOVA. Multivariate least squares modeling was undertaken to investigate the relative roles of demographic predictors of lung function. However, the relatively low sample size of this study limits the power to investigate multivariate relationships robustly and the focus of this investigation was on univariate associations. Correlations with CXRs are presented as Pearson correlation coefficients (r) for the continuous measures of lung function (which have a non-skewed distribution), and ‘‘coefficients of determination’’ (r2) for categorical variables. For all tests, a P-value of less than 0.05 was used for nominal statistical significance. It was determined that ethical approval was not required as the data collection was made retrospectively and anonymously and was not additional to normally collected data.
TABLE 1— Study Group Baseline Characteristics
Baseline characteristics Gender (males/females) Ethnicity European Maori Pacific Island Other Etiology Unknown Post-infectious Primary immunodeficiency Post-oncology disease Other Follow-up period (years)1 Age of diagnosis (years)1 NZDep score (range) CXR (Brasfield) score (n ¼ 70) Chronic HI infection Chronic Pseudomonas infection Digital clubbing Chronic chest deformity Asthma Weight z-score2 Height z-score2 BMI z-score2 FVC % predicted2 (n ¼ 64) FEV1 % predicted2 (n ¼ 64)
NZDep score, New Zealand index of deprivation score; HI, Haemophilus influenzae; BMI, body mass index; FEV1, forced expiratory volume in 1 sec; FVC, forced vital capacity; Other ¼ 7 aspiration, 2 foreign body, 1 burns, and 1 Marfans. 1 Median. 2 Mean.
Maori, 14 European, and 2 Other. Thirty-three (36%) children live in areas with an NZDep score of 10 (most deprived) and 60 (67%) children live in areas scoring 8–10. There was no significant difference in scores over time with a mean NZDep score for the cohort of 9 in 2001 and 8 in 2006. Thirty-eight (42%) children remain with the Respiratory Service (Starship Children’s Health), 18 (20%) had transferred to adult care (age range 16–23 years at end of follow-up), and 1 transferred back to general practitioner care. Eight (9%) children moved from Auckland to within NZ with responses on progress received from 4 cases, 7 (8%) children emigrated to Australia, and 13 (14%) were lost to follow-up.
RESULTS Patient Characteristics
Ninety-one children (49 boys) were identified to have been followed for 5 years since diagnosis. Patient characteristics are summarized in Table 1. This included 53 Pacific Island (25 Samoan, 12 Cook Island Maori, 10 Tongan, 2 Niuean, 1 Fijian, and 3 not further specified), 22
No underlying cause was found for almost half the cases of bronchiectasis (45%) despite extensive investigation. Table 1 outlines the identified underlying etiologies. There was no statistical association between etiology and lung function at baseline or over time (P > 0.05). Pediatric Pulmonology
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Morbidity and Mortality
Thirty-one children (34%) had both finger clubbing and chest wall deformity, six had only finger clubbing (7%), and seven (8%) had chest wall deformity alone. Thirtynine (43%) had neither sign of chronic lung disease. Presence or absence of these signs was not documented in eight children (9%). Thirty-seven (44%) patients had comorbid asthma (n ¼ 85). Overall growth parameters were normal at diagnosis (n ¼ 77) mean height z-score of 0.1 (range 2.8 to þ2.8), a mean weight z-score of 0.1 (range 2.9 to þ2.8) and a mean BMI z-score of 0.3 (range 2.6 to þ2.5). The change in growth over the follow–up period presented as change in z-score per year for height was 0.00 (range 0.40 to þ0.32), for weight was 0.04 (range 0.44 to þ0.79), and for BMI was 0.02 (range 0.82 to þ0.64). There was a significant difference between those of European descent (n ¼ 12), compared to those of Maori (n ¼ 19) and Pacific descent (n ¼ 44) for weight (P ¼ 0.02) and BMI (P ¼ 0.0002) at diagnosis. The presence of clubbing had a significant correlation with lower z scores for height (P ¼ 0.008), weight (P ¼ 0.004), and BMI (P ¼ 0.05). Lower z scores for weight were also seen with presence of chest wall deformity (P ¼ 0.01) and higher (least deprived) NZDep scores of 1–3 (P ¼ 0.02). Six (7%) children died during this follow-up period; two as a direct result of bronchiectasis and 4 from comorbidities. Clinic and Hospital Attendance
Children attended a median of seven clinic visits during the follow-up period (range 1–26) with a ‘‘did not attend’’ rate of 28% for the cohort. Admission data were available for 85 children. Twenty-five (29%) had never required admission for bronchiectasis management, 16 (19%) had required one admission, and 32 (38%) children had required at least annual admissions with a small minority of 5 (7%) needing 3–5 admissions per year. Thirty-three (39%) children had only acute admissions, 14 (16%) had only ‘‘elective’’ admissions, and 13 (15%) had a combination. By the end of the follow-up period, there were 10 (11%) with regular ‘‘elective’’ admissions for intensive treatment commencing between 2000 and 2006 when the children were aged 7–14 years; 5 with 3 monthly admissions, 3 with 6 monthly admissions, and 2 with annual admissions. Sputum Culture
Sputum culture and/or BAL culture was available for 88 children (97%); 42 with sputum cultures, 43 children with both, and 3 with only BAL samples. Figure 2 shows the organisms cultured at diagnosis and then most recently with no significant differences between the beginning and end of the period. Haemophilus influenzae was the most Pediatric Pulmonology
Fig. 2. Sputum culture and/or BAL culture at diagnosis and most recent.
commonly cultured organism with 27 (30%) found to be chronically infected. Only four children were chronically infected with Pseudomonas species. Lung Function
LFTs data were ultimately analyzed in 64 (70%) children who had more than one test, more than 12 months apart. This lung function criteria was not met for 27 children (7 with comorbid developmental delay and 20 who were unable to be followed—7 moved away, 9 lost to follow-up, 4 died). There were a median of 15 LFTs per child (range 2–112) with mean LFT follow-up of 5.8 years (range 1–11.5 years). Table 2 summarizes data for subgroup analysis of bronchiectasis and FEV1. Male gender, comorbid asthma, presence of digital clubbing and chest wall deformity had a significantly lower mean FEV1. There was a similar trend with mean FVC (clubbing P ¼ 0.05, 95% CI 59–74 vs. 69–83; chest deformity P ¼ 0.04, 95% CI 58–73 vs. 70–83). Maori and Pacific Island ethnicity had significantly lower FVC than European children at diagnosis (P ¼ 0.03, mean FVC European 88% CI 76–100; Maori 70% CI 61–80; Pacific Island 69% CI 63–75). FVC was not significantly associated with gender, NZDep, etiology, chronic infection, or asthma. A group of children had a more rapid decline in lung function (41%) with a mean FEV1 loss of 4.4%/ year and this was associated with female gender. The variables used in univariate analysis were gender, ethnicity, NZDep score, etiology, chronic Haemophilus influenzae infection, Pseudomonas colonization, routine admissions, clubbing, chest wall deformity, and asthma. These analyses provided evidence that ethnicity was the greatest predictor of FEV1 at diagnosis explaining about 11% of the variance. Multivariate least squares modeling indicated that ethnicity, gender and NZDep score all had some independent predictive value on FEV1 at diagnosis explaining about 13%, 5%, and 5% of the variance, respectively (P ¼ 0.01, 0.05, and 0.11). There was no significant difference in FEV1 related to etiology or
Outcome of NZ Non-Cystic Fibrosis Bronchiectasis
TABLE 2— Subgroup Analysis of Bronchiectasis and Lung Function Tests (Polgar Reference) Group Gender Male Female Ethnicity European Pacific Island Maori Other Etiology Post-infectious Primary immunodeficiency Post-oncology disease Other Unknown Chronic Haemophilus influenzae No Haemophilus influenzae Asthma No asthma Chest deformity No chest deformity Digital clubbing No digital clubbing NZDep 1–3 4–7 8–10 Chronic Pseudomonas infection No Pseudomonas Routine admissions No routine admissions
% Predicted FEV11 (CI)
% Predicted FEV1/year1
61 (54–68) 72 (64–79)
1.2 (2.7 to þ0.4) 1.1 (2.7 to þ0.9)
81 (68–94) 66 (59–72) 60 (50–70) 41 (10–71)
0.9 (4.1 to þ1.9) 0.7 (2.1 to þ1.1) 2.2 (4.5 to 0.0) —
CI ¼ 95% confidence interval; ns ¼ P > 0.05; NZDep ¼ NZ index of deprivation score. Mean best annual.
chronic sputum bacterial infection. FVC was not significant for all comparisons. FEV1 for the cohort as a whole over the follow-up period declined by a mean of 1.6% predicted/year (Fig. 3). The FEV1 of 30 children declined by a mean of 4.4% predicted/year (range 1 to 17%); FEV1 of 13
children remained unchanged; 21 children improved by a mean of þ3% predicted/year (range þ1% to þ15%). There was a trend towards greater reduction in FEV1 over time associated with Maori ethnicity, high NZDep score, presence of digital clubbing, or chest wall deformity though these did not reach statistical significance (P > 0.05). FVC declined by a mean of 0.7 predicted/year. The FVC of 17 children declined by a mean of 5.8% predicted/year (range 1% to 13%); FVC of 10 children remained unchanged; 37 children improved by a mean of þ6.4% predicted/year (range þ1% to þ22%). FVC was not significant for all comparisons. CXR Scores
Fig. 3. Pictorial representation illustrating the trend in percent predicted FEV1 over time for all patients (n ¼ 64). (NB: The graph represents an ‘‘average’’ patient and assumes a linear relationship extrapolated over 6 years).
The mean Brasfield score for CXR at diagnosis (n ¼ 70) was 18 (range 11–25) and 17.5 (range 6–22.5) at the end (n ¼ 38) of the follow-up period (P ¼ > 0.05). There was a significant correlation with beginning CXR score and concurrent FEV1 and FVC (n ¼ 47, FEV1 r ¼ 0.45, P ¼ 0.001; FVC r ¼ 0.47, P ¼ 0.0008) and end CXR score and concurrent FEV1 and a similar trend with FVC Pediatric Pulmonology
Munro et al.
(n ¼ 26, FEV1 r ¼ 0.59, P ¼ 0.002; FVC r ¼ 0.40, P ¼ 0.05). The rate of change of CXR score versus rate of change of FEV1 and FVC was not significant (n ¼ 26, FEV1 r ¼ 0.04, P ¼ 0.86; FVC r ¼ 0.24, P ¼ 0.24). The presence of chronic Haemophilus influenzae infection was significantly correlated to the CXR score at the end (n ¼ 26, P ¼ < 0.0001, r2 ¼ 0.52) and the change in CXR score over time (P ¼ 0.002, r2 ¼ 0.33). There were no significant relationships with ethnicity, age gender, presumed etiology, digital clubbing, chest wall deformity, asthma, or growth of Pseudomonas species for FEV1 or FVC. DISCUSSION
The main finding of this review is that almost half the children and young people with non-CF bronchiectasis (45%) have declining lung function over time despite follow-up in a tertiary respiratory clinic. However, chronic colonization with Pseudomonas species was rarely seen. Stigmata of chronic lung disease and asthma were associated with poor lung function. Ethnicity, gender, and socioeconomic status appear to be predictive of poor lung function. Sadly, NZ children and young people continue to die from bronchiectasis. In 1969 Field suggested ‘‘it is clear that the patients as a whole improve in the second decade, during puberty, and remain stationary in the third decade.’’16 Bastardo et al.14 have recently described lung function over 2 years (n ¼ 59) as stable (FVC and FEV1 slopes 0.21 and 0.17/ annum, respectively). A subgroup (n ¼ 31) had data spanning 4 years and these also remained stable (FVC and FEV1 slopes 0.009 and 0.107/annum, respectively). The mean deterioration in our group over at least 5 years was 0.7% per annum for FVC and 1.6% per annum for FEV1. This is in keeping with our previous study which showed no change for FVC but a mean decline of 1.9% per annum for FEV1 in the 44 children with bronchiectasis which was not as great as the corresponding mean decline of 1.7% per annum for FVC and of 2.9% per annum for FEV1 in the comparison group of 44 children with CF.21 Yet the FEV1 at baseline was similar in both the Bastardo et al. and this current study—68.3% predicted (prediction equation not stated) and 66% predicted (Polgar), respectively. We found a group of children that appeared to have a more rapid LFT decline (41%) with a mean FEV1 loss of 4.4%/year. This was associated with female gender with a trend for other parameters to have an effect including Ma¯ori ethnicity, high NZDep score, presence of digital or chest wall deformity. Bastardo et al. suggested that a more rapid decline was present in those who had a worse FEV1 at baseline.21 Two papers in adult patients with bronchiectasis have shown that more rapid LFT decline was associated with chronic colonization with Pseudomonas, Pediatric Pulmonology
more frequent severe exacerbations, more systemic inflammation, greater volume of sputum and increased bronchodilator use.19,31 There was no association between etiology and lung function at baseline or over time which is surprising but may be due to small numbers in some etiological categories. Disappointingly, the 10 children who have regular elective admissions for intensive treatment of their bronchiectasis with physiotherapy and IV antibiotics also showed no improvement in lung function over time. We recognize that the findings regarding lung function pertain only to the older and able pediatric group and the findings of deterioration may not apply to the children <5 years of age unable to be measured by this parameter. At baseline, we found lower LFTs were associated with male gender, longevity of disease, Maori and Pacific ethnicity, digital clubbing, chest wall deformity, and comorbid asthma. Digital clubbing was early recognized to be a poor prognostic sign.32 More recently both digital clubbing and chest wall deformity have been associated with higher (more abnormal) HRCT chest scores.33 In a cross-sectional paper in adults, lung function was inversely associated with duration of chronic cough and therefore worse in the group with childhood onset of adult disease.34 Interestingly Field 30 years ago described worsening of symptoms in those with comorbid asthma, and 2 papers from Turkey ascribe asthma as a cause of bronchiectasis.10,35 We found that asthma predicted a slower decline in an earlier study, but the presence of asthma was associated with lower FEV1 at diagnosis in this study. This study could be criticized for scoring CXRs rather than repeat HRCT scans. Also we used the Brasfield score originally created as a CXR score for CF26 in the absence of a CXR score specifically developed for pediatric nonCF bronchiectasis, which includes some features that may not apply to non-CF disease (e.g., nodular lesions). However, scoring repeated CXRs has been standard practice in CF for many years. Most children with nonCF bronchiectasis in this study had several X-rays over time, whereas only 18 had repeat HRCT scans. While there was a relationship between the CXR scores at beginning and end with FEV1, there did not appear to be a correlation over time as the CXR score did not change significantly while the FEV1 deteriorated. This may indicate its insensitivity in particular regarding the area of the lung covered by the domes of the diaphragm and behind the heart. The microbiological results of sputum and BAL cultures are similar to other studies.1,5,14,19 This contrasts with recent adult studies where Pseudomonas has been described in 12–33% patients.36–39 In the current study chronic Haemophilus influenzae infection was associated with a poorer CXR score and in a previous study with more severe disease.21
Outcome of NZ Non-Cystic Fibrosis Bronchiectasis
Unlike in the CF population, failure to thrive is not a regular feature of disease in bronchiectasis. While in central Australia children with bronchiectasis were three times more likely to have had malnutrition in early childhood,40 this has not been reported in our previous series, Alaska, Turkey, or the UK.5,10,41,42 Bastardo et al.14 found that those with reduced FEV1 at baseline also had reduced weight and BMI z scores with the anthropometric measurements not altering over 2 years of follow-up. We found that overall the growth parameters were normal, although were significantly different depending on the ethnic origin of the child. Lower z scores were seen with the presence of clubbing and chest wall deformity, but contradictorily with higher (least deprived) NZDep scores. Children and young people with bronchiectasis in our population are itinerant and the number of outpatient reviews missed at 28% plus 14% lost to follow-up is disappointing. This indicates that follow-up is not optimal, particularly in comparison with the model of care seen in CF.30,43 Building good relationships with children and their families/whanau through cultural competency and the use of culturally appropriate support workers may improve engagement with medical care, as would improving socioeconomic factors (transport, travel costs) aiding healthcare access. Also depressing is that childhood mortality remained significant with 7% of our cohort dying during the follow-up period—high when compared to other pediatric series. In addition, 20% of our cohort transferred to Adult Respiratory Services and now there are between 7 and 12 young people transitioning each year with a formal transition process recently in place. These young people enter their adult lives with significant obstructive lung disease. This study is limited by its retrospective nature. Smoke exposure, active or passive, use of inhaled corticosteroids, the number of prescriptions for, and adherence with, antibiotics was not recorded in this review. Another important factor not addressed is quality of life. Despite management in a tertiary multidisciplinary clinic, almost half the children with bronchiectasis have declining lung function over time. The effect of asthma on bronchiectasis remains to be determined. Although we have a standard approach to care, not dissimilar to a CF care model, we have difficulties in deploying this in our patient group and we are failing to arrest the disease. Better methods to engage and/or improve adherence or new ‘‘easy to deliver’’ treatments are needed. ACKNOWLEDGMENTS
The authors acknowledge the Starship Foundation Fellowship which provided funding for the principal investigator (Dr Karen Munro). Thanks also to Dr Elizabeth Craig (NZ Child and Youth Epidemiology Service) for permission to publish Figure 1.
REFERENCES 1. Twiss J, Metcalfe R, Edwards E, Byrnes C. New Zealand national incidence of bronchiectasis ‘‘too high’’ for a developed country. Arch Dis Child 2005;90:737–740. 2. Saynajakangas O, Keistinen T, Tuuponen T, Kivela SL. The course of childhood bronchiectasis: a case report and considerations of hospital use. Int J Circumpolar Health 1998;57:276– 279. 3. Laverty A, Jaffe A, Cunningham S. Establishment of a web-based registry for rare (orphan) pediatric lung diseases in the United Kingdom: the BPOLD registry. Pediatr Pulmonol 2008;43:451– 456. 4. Twiss J. BPOLD: errors in incidence? Pediatr Pulmonol 2009;44: 625. 5. Edwards EA, Byrnes CA. Paediatric bronchiectasis in the 21st century: experience of a tertiary children’s hospital in New Zealand. J Paediatr Child Health 2003;39:111–117. 6. Bathgate M. The health of Pacific Islands people in New Zealand. Wellington, New Zealand: Public Health Commission; 1994. 7. Craig E. Report on the Health of Pacific Children and Young People in New Zealand. Ministry of Health. New Zealand Child & Youth Epidemiology Service. July 2008, p 339. 8. Clark S. Bronchiectasis in childhood. Br Med J 1963;1:80–88. 9. Wynn-Williams M. Observations on the treatment of bronchiectasis and its relation to prognosis. Tubercle 1957;38:133–145. 10. Karadag B, Karakoc F, Ersu R, Kut A, Bakac S, Dagli E. Noncystic-fibrosis bronchiectasis in children: a persisting problem in developing countries. Respiration 2005;72:233–238. 11. Karakoc F, Dagli E, Gunay I, Bakac S, Yuksel M, Kiyan G, Dagli TE. The outcome and long-term follow-up of children with bronchiectasis. Eur Respir J 1997;10:171s. 12. Gaillard EA, Carty H, Heaf D, Smyth RL. Reversible bronchial dilatation in children: comparison of serial high-resolution computer tomography scans of the lungs. Eur J Radiol 2001;47: 215–220. 13. Eastham KM, Fall AJ, Mitchell L, Spencer DA. The need to redefine non-cystic bronchiectasis in childhood. Thorax 2004;59: 324–327. 14. Bastardo CM, Sonnappa S, Stanojevic S, Navarro A, Lopez PM, Jaffe A, et al. Non-cystic fibrosis bronchiectasis in childhood: longitudinal growth and lung function. Thorax 2009;64:246– 251. 15. Haidopoulou K, Calder A, Jones A, Jaffe A, Sonnappa S. Bronchiectasis secondary to primary immunodeficiency in children: longitudinal changes in structure and function. Pediatr Pulmonol 2009;44:669–675. 16. Field CE. Bronchiectasis. Third report on a follow-up study of medical and surgical cases from childhood. Arch Dis Child 1969;44:551–561. 17. Glauser EM, Cook CD, Harris GB. Bronchiectasis: a review of 187 cases in children with follow-up pulmonary function studies in 58. Acta Paediatr Scand 1966; 1–16. 18. Ellis DA, Thornley PE, Wightman AJ, Walker M, Chalmers J, Crofton JW. Present outlook in bronchiectasis: clinical and social study and review of factors influencing prognosis. Thorax 1981;36:659–664. 19. King PT, Holdsworth SR, Freezer NJ, Villanueva E, Gallagher M, Holmes PW. Outcome in adult bronchiectasis. COPD 2005;2: 27–34. 20. Sheehan RE, Wells AU, Copley SJ, Desai SR, Howling SJ, Cole PJ, et al. A comparison of serial computed and functional change in bronchiectasis. Eur Respir J 2002;20:1–7. 21. Twiss J, Stewart AW, Byrnes CA. Longitudinal pulmonary function of childhood bronchiectasis and comparison with cystic fibrosis. Thorax 2006;61:414–418.
Munro et al.
22. Edwards E. Paediatric bronchiectasis in Auckland, New Zealand—non-invasive screening for ciliary disease and airway inflammation. Auckland: University of Auckland; 2003. 23. Standardization of Spirometry, 1994 Update. American Thoracic Society. Am J Respir Crit Care Med 1995;152:1107–1136. 24. Polgar G, Promadhat V. Pulmonary function testing in children: techniques and standards. Philadelphia: WB Saunders; 1971. 25. Pellegrino R, Viegi G, Brusasco V, Crapo RO, Burgos F, Casaburi R, et al. Interpretative strategies for lung function tests. Eur Respir J 2005;26:948–968. 26. Brasfield D, Hicks G, Soong S, Peters J, Tiller R. Evaluation of scoring system of the chest radiograph in cystic fibrosis: a collaborative study. AJR Am J Roentgenol 1980;134:1195–1198. 27. Salmond C, Crampton P. NZDep2001 index of deprivation. Wellington: Department of Public Health, Wellington School of Medicine and Health Sciences; 2002. 28. Chang AB, Grimwood K, Maguire G, King PT, Morris PS, Torzillo PJ. Management of bronchiectasis and chronic suppurative lung disease in indigenous children and adults from rural and remote Australian communities. Med J Aust 2008;189:386– 393. 29. Edwards EA, Twiss J, Byrnes CA. Treatment of paediatric noncystic fibrosis bronchiectasis. Expert Opin Pharmacother 2004;5: 1471–1484. 30. Chang AB, Grimwood K, Mulholland EK, Torzillo PJ. Bronchiectasis in indigenous children in remote Australian communities. Med J Aust 2002;177:200–204. 31. Martinez-Garcia MA, Perpina-Tordera M, Roman-Sanchez P, Soler-Cataluna JJ. Quality-of-life determinants in patients with clinically stable bronchiectasis. Chest 2005;128:739–745. 32. Strang C. The fate of children with bronchiectasis. Ann Intern Med 1956;44:630–656. 33. Edwards EA, Metcalfe R, Milne DG, Thompson J, Byrnes CA. A retrospective review of children presenting with non-cystic
fibrosis bronchiectasis: HRCT features and clinical relationships. Paediatr Pulmonol 2003;36:87–93. King PT, Holdsworth SR, Farmer M, Freezer N, Villanueva E, Holmes PW. Phenotypes of adult bronchiectasis: onset of productive cough in childhood and adulthood. COPD 2009;6: 130–136. Karakoc GB, Yilmaz M, Altintas DU, Kendirli SG. Bronchiectasis: still a problem. Pediatr Pulmonol 2001;32:175–178. Angrill J, Agusti C, de Celis R, Rano A, Gonzalez J, Sole T, et al. Bacterial colonisation in patients with bronchiectasis: microbiological pattern and risk factors. Thorax 2002;57:15–19. Nicotra MB, Rivera M, Dale AM, Shepherd R, Carter R. Clinical, pathophysiologic, and microbiologic characterization of bronchiectasis in an aging cohort. Chest 1995;108:955–961. King PT, Holdsworth SR, Freezer NJ, Villanueva E, Holmes PW. Microbiologic follow-up study in adult bronchiectasis. Respir Med 2007;101:1633–1638. Pasteur MC, Helliwell SM, Houghton SJ, Webb SC, Foweraker JE, Coulden RA, et al. An investigation into causative factors in patients with bronchiectasis. Am J Respir Crit Care Med 2000; 162:1277–1284. Valery PC, Torzillo PJ, Mulholland K, Boyce NC, Purdie DM, Chang AB. Hospital-based case-control study of bronchiectasis in indigenous children in Central Australia. Pediatr Infect Dis J 2004;23:902–908. Singleton R, Morris A, Redding G, Poll J, Holck P, Martinez P, et al. Bronchiectasis in Alaska Native children: causes and clinical courses. Pediatr Pulmonol 2000;29:182–187. Li AM, Sonnappa S, Lex C, Wong E, Zacharasiewicz A, Bush A, et al. Non-CF bronchiectasis: does knowing the aetiology lead to changes in management? Eur Respir J 2005;26:8–14. Kerem E, Conway S, Elborn S, Heijerman H. Standards of care for patients with cystic fibrosis: a European consensus. J Cyst Fibros 2005;4:7–26.