constrictive pericarditis is offered on the basis of 6 patients studied clinically and by right heart catheterization. In 2 cases intermittent tamponade in the presence ...
Catecholamine and Vasopressin Stimulation of Gluconeogenesis from. Dihydroxyacetone in the Presence of Atractylosideâ. (Received for publication, July 23 ...
Spink, W. W., J. Reddin, S. J. Zak, M. Peterson, B. Starzecki ... Thomas, L. The role of epinephrine in the reactions ... Zweifach, B. A., A. L. Nagler, and L. Thomas.
 Shannon RP, Komamura K, Stambler BS et al. Alterations in in part by US Public Health Service Grants HL-59070 and myocardial contractility in conscious ...
Background: Deep vein thrombosis (DVT) is a major complication in critical care. There are various ... compression (IPC) or compression stockings, or early administration of ... prolonged periods. Some reports suggest that EMS may ..... Collaboration
Cardiovascular changes in response to real-life or laboratory-induced ..... intervals between successive normal complexes are determined (Malik & Camm, .... are similar to those observed in heart failure patients or heart transplant patients (Arora .
Sep 17, 2008 - Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; 2FM Kirby ... Krieger Institute, Baltimore, Maryland, USA; 3Oxford Centre for Functional MRI ...... al resting potential and recycling neurotransmitters,.
in Friston et al.  clearly did not use flow as input. Balloon Model. O2. Demand ...... sonance in Medicine, 39, 41-52. doi:10.1002/mrm.1910390109.  Fritson ...
Mar 26, 1970 - 157/109. 134/100. 137/95. 3.2. 4.5. 4. 96. 148/99. 154/81. 157/99. -0.4. 1.8 ... 110/80t. 138. 130/85. 113/82. 98/75. 2.5. 3.2t. 3.5. 3.0. 125/90: 126. 144/106 ..... 0 00 ob x# 150. 20. E. E. El. 0. B. 2mOO0- 250- o). ] IO a .0. 0-. 0.
Acute and chronic pyelonephritis. 9. 42. Male ... Pulmonary tuberculosis; pulmonary emphysema. 14. 53 ... Chronic alcoholism; pulmonary emphysema; dia-.
In March 2009, Kol IO et al 8 conducted a study on the effects of IV ephedrine 0.5 mg/kg during spinal anesthesia for cesarean delivery. The findings suggest.
Oct 22, 1987 - pre/post approach to study 7 male and 5 female adults through a .... In summary, this (largely) Scandinavian research shows that when in- ..... While the primary question of an exercise-to-temperament link is answered ... agree that ca
Poli de Figueiredo (in memoriam),II Maria JoseÂ´ C. CarmonaI. I Hospital das ClÄ±nicas da Faculdade de Medicina da Universidade de SaËo Paulo, ...
Chronic clorgyline treatment had no significant effect on the CSF concentrations of HVA and ..... A. E. Felner and P. C. Waldmeier, Biochem. Pharmac. 28, 995 ...
Stimulation of catecholamine release was studied in the isolated adrenal of the cat during retrograde perfusion. Theophylline, adenosine 3': 5'-cyclic monophos-.
A control group of six anesthetized dogs was studied at normal body temperatures for four to six hours following coronary embolization. Of the total of 38 dogs, the chest was kept closed in all except 9 hypothermic animals in which left ventricular c
Objectif: Comparer les effets circulatoires du pantalon antichoc (PAC) chez des patients ventil& .... sure were -1.8/0.6, -1.8/0.6, -1.8/2.4, -1.8/0.6 mmHg at base-.
Sin embargo, el levosimendÃ¡n ejerce un efecto vasodilatador inespecÃfico capaz de provocar hipo- tensiÃ³n arterial. En estos pacientes es recomendable re-.
Chen, Ling, and Steven M. Scharf. Comparative hemo- dynamic effects of periodic obstructive and simulated central apneas in sedated pigs. J. Appl. Physiol.
derangements including increased gluconeo- genesis, impaired .... kidney counts within 5% was used as an in- ... were removed for microsphere counting. Tis-.
including mean left atrial pressure (LAP, in mm Hg), mean pulmonary artery pressure ... 6; tricuspid atresia n ..... long-term effects of pacing on the Fontan circuit.
Aug 21, 1974 - Medicine and Physiology, University of California at Davis, School of Medicine ... Supported in part by Research Program Project Grant HL 14780 .... cls c,] o a a-/. RtS. Ob~. 00l c; a. Cd. oI b. "a-. 0 so. C(2. Q. 0. "a-C. sH a .cJ.
Hemodynamic Effects of Catecholamine Stimulation in Constrictive Pericarditis By FRED K. NAKHJAVAN, M.D.,
HARRY GOLDBERG, M.D.
SUMMARY Cardiac hemodynamic studies during control resting state and isoproterenol infusion performed on five patients with constrictive pericarditis. During isoproterenol infusion, stroke volume increased by 60%, while there was no significant change in pulmonary wedge and right atrial mean pressures. The relatively fixed filling pressure is the indirect evidence of fixed diastolic size of the heart. However, the fixed cardiac size in diastole per se does not necessarily indicate hindrance to filling of the heart unless the limits of diastolic size of the heart are reached. It is concluded that during the supine resting state, when the influence of catecholamines is minimal, systolic emptying of ventricles is hindered. The systolic hindrance is, however, overcome by strong positive inotropic stimulation. were
Downloaded from http://circ.ahajournals.org/ by guest on November 8, 2017
gated. To study the emptying ability of the heart in constrictive pericarditis, a strong inotropic agent, such as isoproterenol, seems to be ideal, especially since the diastolic size of the heart is fixed. It is the purpose of this communication to report the hemodynamic influence of isoproterenol infusion on five patients with constrictive pericarditis who were subjected to cardiac catheterization studies. Methods
IT IS generally agreed that in constrictive pericarditis there is "hindrance of ventricular filling."' Whether or not there is also systolic impediment to ventricular emptying is debatable. Sawyer and associates2 in 1952, in their report on constrictive pericarditis, raised the possibility "that the thick pericardial scar itself may interfere with ventricular contraction." Lindell and associates3 in 1963 reported an increase in the stroke volume in patients with constrictive pericarditis during intravenous histamine infusion. They suggested that "the fact that ventricular output may be increased by pharrnacological agents indicates the importance of factors that hinder ventricular emptying." Zimmerman4 also has stated that in constrictive pericarditis there is impairment of ventricular ejection. The hemodynamic characteristics of constrictive pericarditis are well described;" 2, 4-6 but the effects of positive inotropic stimuli on such hearts have not been thoroughly investi-
Five patients formed the material of this study. All the patients had had symptoms referable to constrictive pericarditis for several years. Complete history and physical examination, chest roentgenogram, a 12-lead electrocardiogram, carotid tracing, and phonocardiogram were obtained on all. Diagnosis of constrictive pericarditis was made on all the patients and confirmed by cardiac catheterization. Three patients were operated on subsequently (cases 1, 2, and 3). Patient 4 has not consented to operation. Patient 5 has a severe coagulation defect and protein-losing gastroenteropathy and is being prepared for operation. All the patients except one (case 1) had calcification of the pericardium. Right heart catheterization was performed in the postabsorptive state after premedication with 50 mg each of pentobarbital
From the Department of Cardiology (WLMR), Albert Einstein Medical Center, Northern Division, Philadelphia, Pennsylvania. Received April 29, 1970; accepted for publication May 20, 1970. Circulation, Volume XLIl, September 1970
sodium and diphenhydramine hydrochloride. Cardiac output was determined by direct Fick
Cardiac Hemodynamic Data on Five Patients with Constrictive Pericarditis Case
C I C I C I C I C I
Age (yr) & sex
107 NSR 135 NSR 72 AF 100 AF 73 AF 149 AF 84 NSR 110 NSR 86 NSR 103 NSR
A-V 02 CI
2.33 4.31 2.52 4.49 2.30 7.34 2.45 3.71 2.05 3.60
133.7 123.6 125.6 114 176 127.3 196.3 100.5 115.3
Downloaded from http://circ.ahajournals.org/ by guest on November 8, 2017
4.9 3.1 4.9 2.8 4.8 2.4 5.2 5.3 4.9 3.2
34.4 35 45 32 51 29 34 23
Art. 02 sat. (%)
98 99 98 99 99 1(V)
9'i 94 9
97 1.0 0.8
Abbreviations: AF = atrial fibrillation; BA = brachial artery; BSA = body surface area; C = control; CI = cardiac index; D = diastolic; I = isoproterenol; M = mean; NSR = normal sinus rhythm; PA = pulmonary artery; PAR = pulmonary arteriolar resistance; RA = right atrium; RV = right ventricle; S = systolic; SI = stroke index; TPVR = total pulmonary vascular resistance; TSVR = total systemic vascular resistance.
principle. Pressures were measured by Statham transducers, model 23 Db. Mean pressures were measured by electrical integration. The zero reference level was set at 5 cm below the sternum. Cardiac output and pressures were measured during control state and were repeated during an intravenous infusion of isoproterenol (1 ,.tg/ml). The rate of isoproterenol infusion was titrated until a satisfactory chronotropic response was steadily maintained. All the recordings were made on an Electronics for Medicine photographic recorder, model DR-8. Results
The cardiac catheterization data are demonstrated in table 1. Cardiac Index
Isoproterenol infusion caused an increase in cardiac output in all the patients. The mean increase was 2.36 L/min/m2 or 102%. Systemic arteriovenous oxygen difference diminished in four patients and did not change in one (case 4). In this patient the increase in cardiac output was mainly due to an increase in oxygen uptake. Stroke Index
Of particular interest was the increase in stroke index which occurred in every patient
during isoproterenol infusion. The mean increase was 15 ml/beat/mn or 60%. Pulmonary Arterial and Wedge Pressures
During the control state, pulmonary wedge pressure was elevated in each case and revealed the characteristic "W" or "M" configuration. After isoproterenol infusion, there was no significant change in wedge pressure. The change in pulmonary arterial pressure was also insignificant. Right Ventricular Pressure
During control state, right ventricular enddiastolic pressure was elevated in all the patients and the tracing revealed a typical "dip and plateau" configuration. During isoproterenol infusion, right ventricular pressure was obtained in three patients (cases 3, 4, and 5) and did not reveal a significant change. Right Atrial Pressure
The tracing revealed a typical M or W configuration. The right atrial mean pressure in the control state was elevated in all the patients. In the four patients, whose right atrial pressure was recorded during isoproterenol infusion, no significant change occurred. Circulation, Volume XLII, September 1970
17 13 12 1 n 23 5"3 16 16 Downloaded from http://circ.ahajournals.org/ by guest on November 8, 2017
28 27 27 30 32 32 40 41 29 33
16 17 12 12 12 12
2a 25 16 16 0.2 1.2
20 20 17 18 17 18 28 30 20 24
Pressures (mm Hg) RV S D
32 30 40 42 30 33
11 12 20 20 13 12
7 6 10 9 19 20 13 13
Brachial Arterial Pressure
Isoproterenol caused a moderate rise in brachial arterial systolic, diastolic, and mean pressures in cases 1, 4, and 5. Vascular Resistances
During isoproterenol infusion there was diminution in the total pulmonary vascular resistance in all the patients with a mean reduction of 144 dynes sec cm-5 (-43%). Pulmonary arteriolar resistance decreased in three patients (cases 1, 2, and 3) and showed no significant change in cases 4 and 5. Total systemic vascular resistance decreased in all the patients during isoproterenol infusion with a mean reduction of 564 dynes sec cm-5
The two interesting findings in the present study are: (1) the relatively fixed enddiastolic pressure, and (2) the increase in stroke volume during isoproterenol infusion. In constrictive pericarditis, the diastolic size of the heart is essentially fixed because of restriction by a tense fibrous or calcified pericardium. The fixed diastolic size of the heart deprives the heart of volume changes and hence the Frank-Starling mechanism. In the present study, the end-diastolic volume of the heart was not measured; however, we Circulation, Volume XLII, September 1970
103 122 115 112 122 127 132 155 80 92
64 70 58 64 78 66 70 80 44 64
80 88 82 82 86 80 80 90 56 72
Vascular resistance (dynes sec cm-5) TSVR TPVR PAR
390 212 266 156 298 101 362 256 410 282
60 21 78 52 88 40 65 60 82 94
1570 932 1280 720 1500 452 1040 770 1150 845
have assumed that the changes in enddiastolic pressure "in a low compliant chamber" are indicative of changes in volume. Is the above assumption correct? Isaacs and associates7 have demonstrated that in constrictive pericarditis, because of decreased compliance, the pressure-volume curve of the heart is essentially steep. It is a fact that in the steep portion of any pressure-volume curve, small changes in volume are reflected fairly accurately in changes in pressure. Hence, in the present study the relatively fixed pulmonary wedge pressure and right atrial pressure during control state and isoproterenol infusion are indicative of a fixed diastolic volume of the heart. The relatively fixed end-diastolic pressure of the ventricles in constrictive pericarditis is in marked contrast to the effect of isoproterenol in normal and diseased hearts where enddiastolic pressure and volume diminish.8 9 ,Gould and associates9 have demonstrated that in nonobstructive primary myocardial disease, isoproterenol increased the stroke index (+32%) and decreased the left ventricular enddiastolic pressure (-41%). In the present study, on the other hand, the filling pressure of the heart was not significantly altered after isoproterenol infusion, while stroke index increased 60%. The increase in stroke volume
Downloaded from http://circ.ahajournals.org/ by guest on November 8, 2017
in the present study is similar to the finding of Lindell and associates3 during intravenous histamine infusion and is due to better emptying of the heart. In constrictive pericarditis, after a more complete systolic emptying, the heart "must" return to its fixed diastolic size. In this regard, there is no hindrance to filling until the limits of diastolic size of the heart are reached. In this study, cardiac output and stroke volume at rest and in supine position were diminished or were at lower limits of normal in all the patients. The most likely explanation is that at rest in the supine position where the influence of catecholamine stimulation is minimal, and the "systolic emptying of the heart is hindered." However, during inotropic stimulation, the systolic hindrance is overcome by a more forceful contraction and hence by better emptying of the heart and an increase in the stroke volume. This effect of catecholamine stimulation may explain the observed increase in the stroke volume during supine exercise in patients with constrictive pericarditis.10 Two extremes of the disease must be considered in this pathophysiologic picture. First is when the constriction is so mild that the diastolic size of the heart may change to some extent. The other situation is when the myocardium is so severely atrophied or so extensively involved in the fibrocalcific process of the pericardium that it is not capable of responding to inotropic stimuli. The cases
reported in the present communication do not seem to belong to either of the above two categories. References 1. SPODICK DH: Chronic and Constrictive Pericarditis. Grune & Stratton, Inc, New York, 1964 2. SAWYER CG, BURWELL CS, DEXTER L, ET AL: Chronic constrictive pericarditis: Further con-
7. 8. 9.
sideration of the pathologic physiology of the disease. Amer Heart J 44: 207, 1952 LINDELL SE, SVANBOR A, SODERHOLM B, ET AL: Hemodynamic changes in chronic constrictive pericarditis during exercise and histamine infusion. Brit Heart J 25: 35, 1963 ZIMMERfAN HA: Intravascular Catheterization, ed 2. Springfield, Illinois, Charles C Thomas Publishers, 1966 HARVEY RM, FERRER MI, CATHCART RT, ET AL: Mechanical and myocardial factors in chronic constrictive pericarditis. Circulation 8: 695, 1953 WooD P: Constrictive pericarditis. Amer J Cardiol 7: 48, 1961 ISAACS JP, CARTER N II, HALLER HA: Experimental pericarditis. Bull Johns Hopkins Hosp 90: 259, 1952 ELLIOTT WC, GoRLIN R: Isoproterenol in treatment of heart disease. JAMA 197: 315, 1966 GouLD L, ZAHIR M, CALDER B, ET AL: Nonobstructive primary myocardial disease: Hemodynamic studies in fourteen cases. Amer J Cardiol 22: 523, 1968 McHENRY MM, ORD JW, JOHNSTON RR, ET AL: Exercise performance and stroke volume changes in two patients with constrictive pericarditis. Amer Heart J 70: 180, 1965
Circulation, Volume XLII, September 1970
Hemodynamic Effects of Catecholamine Stimulation in Constrictive Pericarditis FRED K. NAKHJAVAN and HARRY GOLDBERG Downloaded from http://circ.ahajournals.org/ by guest on November 8, 2017
The online version of this article, along with updated information and services, is located on the World Wide Web at: http://circ.ahajournals.org/content/42/3/487
Permissions: Requests for permissions to reproduce figures, tables, or portions of articles originally published in Circulation can be obtained via RightsLink, a service of the Copyright Clearance Center, not the Editorial Office. Once the online version of the published article for which permission is being requested is located, click Request Permissions in the middle column of the Web page under Services. Further information about this process is available in the Permissions and Rights Question and Answer document. Reprints: Information about reprints can be found online at: http://www.lww.com/reprints Subscriptions: Information about subscribing to Circulation is online at: http://circ.ahajournals.org//subscriptions/