MYC Regulation of CHK1 and CHK2 Promotes

Apr 13, 2017 - The cancer stem cell (CSC) hypothesis provides a framework for ... prospect of human CSC isolation. Recent ...... Cancer Biol 2002;12:4...

0 downloads 0 Views 3MB Size

Recommend Documents

... for publication but have not yet been edited. Author Manuscript Published OnlineFirst on December 26, 2012; DOI: 10.1158/0008-5472.CAN-12-1408 ...

Ricerca sul Cancro (AIRC: MFAG 2013 #14641 and Triennial. Fellowship “Antonietta Latronico”, 2014), Ministero Italiano della Salute (RF_ GR-2011-02351355), the Programma per i. Giovani Ricercatori “Rita Levi Montalcini” 2011 and Ligue. Nation

Aug 1, 2001 - c Sarcoma, brain tumor, leukemia, tumors of adrenal cortex, and breast cancer. Table 2 Mutations found in .... 593(14) C3T. 2 (1 homozygote).

Mar 4, 2013 - with the most significant and robust interaction, and it was validated using AZD7762, a small-molecule ATP-competitive inhibitor of CHK1 ...

Institutionen för Mikrobiologi, Tumör och Cellbiologi. MYC AND MNT IN ...... the simian virus 40 large T oncoprotein and H-RAS (Hahn et al., 1999). The hTERT ...

Jul 28, 2017 - 200025, China. 2. Department of ... This molecule was identified as a metastasis suppressor gene in human breast ... assay. As shown, NDRG1 was differently expressed among these cell lines and ..... CD86, CD166, and death receptors [39

Dec 21, 2014 - control expression of an extensive network of downstream transcriptional targets [9,19-28]. Early ..... Orian A, van Steensel B, Delrow J, et al.

myc RNA as a component of either polyadenylate-containing or .... II activity (Å“P .... ô> o co p —i. OI. Fig. 1. DNA "dot blot" comparing c-myc copy numbers in ...

lates Chk2 on threonine 68, which promotes oligomeri- zation and phosphorylation on threonines 383 and 387 within the activation loop of the catalytic domain.

directly regulates glucose metabolism and mitochondrial biogenesis in cardiac ..... Electron microscopy was performed on myocardial sections from .... enhanced after stress in the heart for some time (for review, see refs. ..... 2001;14(1):45–55.

family member p73 as checkpoints to regulate apoptosis (Aloyz et al., 1998; Pozniak et al., 2000a). Thus, both the survival and terminal mitosis of sympathetic ...

HL60 cells knocked down for c-Myc expression exhib- ited reduced calpain activity ... molecules such as BCL-2 are also up-regulated. c-Myc is a very labile .... film processor. The primary ..... however, these measurements were performed in cell-free

Apr 8, 2017 - numbers of the c-myc gene into a human melanoma cell line is correlated with ...... cogene expression in subungual melanoma. Br J Plast.

7 or 35 days, transferred CD8+ Thy1.2+ T cells from the spleens and LNs of the .... duced with retroviral vectors expressing GFP alone (Mig),. GFP with c-Myc ...

Jan 23, 2014 - Regulation of MYC Expression and Differential JQ1 ... 4 Simmons Comprehensive Cancer Center, University of Texas .... anol solution (Invitrogen) and 10% Fetal Calf Sera (Atlanta ... mRNA via linear equations specific to each primer pai

Mar 17, 2017 - of 4-OHT in tamoxifen resistant cell line MCF-7/TAM. Furthermore, we confirmed aspirin's anti-tumor function and potential role in overcoming ...

Oct 3, 2012 - The serrated pathway includes lesions with “saw-tooth” crypt morphology like hyperplastic polyps, sessile serrated adenoma, traditional.

May 21, 2015 - In the absence of prior irradiation, however, mitotic catastrophe could be induced with inhibitors against CHK1. (AZD7762) or WEE1 (MK-1775).

transcriptional regulation by the 'Max network' has emerged ... The Max-interaction network ..... have both unique and overlapping binding sites (Orian et al.,.

Jan 27, 2015 - Research Center for Developmental Biology and Regenerative Medicine, National .... normal (n = 7) (Oncomine) (Supplementary Figure ... exclusion assays show that knockdown of C1GALT1 ... [26] and protects breast cancer cells from immun

Correspondence to: Shu Li, email: [email protected] Keywords: broiler, spleen ... microRNA-155 on apoptosis in the spleen of selenium-deficient broilers. We replicated ...... 2016; 7:84508–19. doi: 10.18632/oncotarget.13022. 28. Tili E ...

Jun 14, 2017 - itabine and inhibited the CSC and EMT phenotypes in GR cells both in vitro and in vivo. Intriguingly, the ...... J Cell Physiol. 2012; 227: 421–30.

Feb 9, 2017 - ... Xian Du2,*, Yafeng Song1, Lin Fan3, Fuyan Li1, Yan Gao1, Ruimin Wu1, ..... Xu W, Chen Z, He A, Zhang Q, Sun X, Zhao G and Huang.

bovine pancreatic insulin (Sigma), and 2.5 μg plasmocin. (Invivogen). TamR-MCF-7 cells were cultured in phenol red free IMEM + 5 % charcoal stripped FBS, ...