MYC Regulation of CHK1 and CHK2 Promotes

Apr 13, 2017 - The cancer stem cell (CSC) hypothesis provides a framework for ... prospect of human CSC isolation. Recent ...... Cancer Biol 2002;12:4...

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... for publication but have not yet been edited. Author Manuscript Published OnlineFirst on December 26, 2012; DOI: 10.1158/0008-5472.CAN-12-1408 ...

Ricerca sul Cancro (AIRC: MFAG 2013 #14641 and Triennial. Fellowship “Antonietta Latronico”, 2014), Ministero Italiano della Salute (RF_ GR-2011-02351355), the Programma per i. Giovani Ricercatori “Rita Levi Montalcini” 2011 and Ligue. Nation

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Mar 4, 2013 - with the most significant and robust interaction, and it was validated using AZD7762, a small-molecule ATP-competitive inhibitor of CHK1 ...

proteolysis and together support the view that c-Myc promotes G1 exit in part via Cul1-dependent ubiquitination and degradation of the CDK inhibitor, p27kip1.

video recorders (Sony M370CE and PVW-2800P, respectively), and driven by Broadcast Animation Controllers (BAC 900) were used. Films were viewed on a ...

Institutionen för Mikrobiologi, Tumör och Cellbiologi. MYC AND MNT IN ...... the simian virus 40 large T oncoprotein and H-RAS (Hahn et al., 1999). The hTERT ...

Jun 2, 2009 - in transformed cells by various mechanisms including mutations in the gene for .... antibiotics (Bio-Whittaker Europe, Verviers, Belgium), and maintained at ... for general transcription activity by PCR using the following prim- ers: Ju

lates Chk2 on threonine 68, which promotes oligomeri- zation and phosphorylation on threonines 383 and 387 within the activation loop of the catalytic domain.

Jul 28, 2017 - 200025, China. 2. Department of ... This molecule was identified as a metastasis suppressor gene in human breast ... assay. As shown, NDRG1 was differently expressed among these cell lines and ..... CD86, CD166, and death receptors [39

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directly regulates glucose metabolism and mitochondrial biogenesis in cardiac ..... Electron microscopy was performed on myocardial sections from .... enhanced after stress in the heart for some time (for review, see refs. ..... 2001;14(1):45–55.

This document has been made available through Purdue e-Pubs, a service of the Purdue .... 6. T-MYC is detected with two antibodies generated to detect the C-terminus of MYC . 16 ..... C-terminus of MYC made by Sigma Aldrich and Abcam. ..... The treat

The Semenza and Dang labs further show that HIF1 ...... Cell 107(1), 43-54. Evan, G.I., Wyllie, A.H., Gilbert, C.S., Littlewood, T.D., Land, H., Brooks, M., Waters,.

approximately doubled the transcription rate of e-myc by reversing the ... also been inve~tigated.~~”~. GM-CSF ...... Blood 76:706,1990. 30. Caracciolo D ...

myc RNA as a component of either polyadenylate-containing or .... II activity (Å“P .... ô> o co p —i. OI. Fig. 1. DNA "dot blot" comparing c-myc copy numbers in ...

family member p73 as checkpoints to regulate apoptosis (Aloyz et al., 1998; Pozniak et al., 2000a). Thus, both the survival and terminal mitosis of sympathetic ...

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chemical evidence that Myc can induce cell proliferation, link. Myc's function to ... the HLH-LZ motif with a similar structure in the Max protein, the DNA binding ...

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