Phase I Clinical and Pharmacologic Study of

Departments of Pediatric Hematology/Oncology, State University of. New York Upstate Medical University, .... Downloaded from ..... Neuro-Oncology, 4: ...

0 downloads 0 Views 152KB Size

Recommend Documents

Jun 1, 2005 - Nancy Harold,2,3,5 Suzanne Fioravanti,2,3,5 Barbara Schuler,2,3,5 Brian P. Monahan,6. M.Wasif Saif ...... TATA-less bidirectional human thymidylate synthase promoter. ... nomics: road to anticancer therapeutics nirvana? On-.

most frequent grade 3 to 4 toxicity was myelosuppression. .... Dex/Thal. 16. 89. Bortezomib. 16. 89. Melphalan. 9. 50. Abbreviations: CLL, chronic lymphocytic leukemia; MM, ... dem mass spectrometry assay with a lower limit of quantification of 0.5 n

followed by Cisplatinum and 5-Fluorouracil in Patients with. Advanced Solid Tumors. Kapil N. Bhalla,1 Gondi N. Kumar,. U. Kristina Walle, Ana Maria Ibrado,.

Sep 15, 2006 - metastases in multiple solid tumors, including bladder, breast, esophagus, oral .... Australia) in glass vials containing 400 mg sterile lyophilized powder. .... 88 dose, day 28, and, for part 1 of the study only, days 5 and 19. Blood

Apr 18, 2017 - checkpoint interruption with the Chk1/Chk2 inhibitor. AZD 7762 (35). In the present study, only 2 of 10 (20%) patients with a complex karyotype ...

Mar 15, 2008 - cycle of therapy was 805/ul and the median platelet nadir was 48,000/ul. Other toxic .... This was achieved using a Waters model 510 pump and ...

Val and 5-methylbenzoic acid form the lateral chain. The cycled region ...... (M)/prednisone (P) in men with androgen independent prostate cancer. J Clin Oncol ...

(/')determined the human pharmacokinetics of the drug on a. 6-h infusion ..... dexamethasone, and/or aminophylline were required to treat the reactions.

POH was formulated in soft gelatin capsules con- .... Drug Formulation. ... phase I design. .... No significant problems with myelosuppression were seen. Grade 1 ...

Mar 15, 2008 - nary function defined as a carbon monoxide diffusion capacity of at least 80% of predicted and a ... UV detection was accom plished using a ...

Phase I and Clinical Pharmacology Study of Intravenous Flavone Acetic Acid. (NSC347512)1 .... tration was achieved by evaporation under nitrogen. A standard ...

Antisense Oligonucleotide ISIS 3521 Administered in Combination with 5-Fluorouracil and Leucovorin in Patients with. Advanced Cancer1. Sridhar Mani,2 ...

Jul 15, 1995 - Phase I Clinical and Pharmacological Study of Suppression of Human Antimouse. Antibody ... V. V., D. B., H. W., G. H.¡,Laboratory Medicine ¡H.F.], and Clinical Immunology and Biological Therapy [J. L M.],. The University of ....

staurosporine family of agents, which have two indole nitrogens linked to a carbohydrate residue. Representatives from both of these subgroups have been the ...

to the antifolate drugs trimetrexate, metoprine, homofolate, and CB3717 in human lymphoma and osteosarcoma cells resistant to methotrexate. Cancer. Res.

ables was determined by the Pearson correlation coefficient. .... the plasma levels to increase with higher doses (Pearson corre- ..... Vss (observed) (liters/m2).

infusion solutions are compatible with PVC i.v. infusion bags and are chemically stable ... two cycles of treatment. Disease assessments by any tech- ...... Click on "Request Permissions" which will take you to the Copyright Clearance Center's.

anemia, and brief transaminasemia. One patient who received antibody alone had an apparent acute immune complex-mediated reaction. Ten of. 11 patients ...

Heinrich, M. C. SU5416 and SU5614 inhibit kinase activity of wild-type and mutant FLT3 receptor tyrosine kinase. Blood, 100: 2941–2949,. 2002. 8. O'Farrell ...

technique. INTRODUCTION. DNA intercalating agents, including anthracyclines such as doxorubicin, have been used for many years in the treatment of patients with cancer. However, prolonged treatment with many of these compounds can result in cardiotox

in Serum of Cancer Patients: Phase I Clinical Trial. Jose A. Baptista,1 ... (1), sub- sequently from. North. American plants of the ganera. Astragulus .... Gal in H20.

Nov 8, 2012 - Running Head: Sorafenib, bevacizumab, and cyclophosphamide in solid .... humanized monoclonal antibody that binds directly to all four VEGF ...

derived from breast (MDA-MB-435), colorectal (RKO, HT-29, ..... 2019. 625. 1857. 1077. 4208. 2903. 2434. Ctrough e (ng/ml). Ro 31-7453. 54.2. 145. 72. 361.

Jul 15, 2006 - suggested that G1 arrest induced by EGFR TKI interferes with the cell cycle .... Dassonville O, Formento JL, Francoual M, et al. Expression of ...