QUANTITATIVE ANALYSIS OF p53 PROTEIN IN

usually assessed by immunohistochemical techniques, for the prognosis of lung .... invasive or small cell histologic type, were judged to be non- rese...

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as, in humans, there exist a number of fatal disorders in which peroxisomes fail to import PTS1-containing enzymes [12, 13]. Peroxisome biogenesis disorders ...

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3 De Novo Pharmaceuticals, Compass House, Vision Park, Histon, Cambridge, CB4 9ZR, UK. The design, synthesis and evaluation of 24 isoindolinones as potential inhibitors of the MDM2-p53 interaction is described. The most potent inhibitor NU8231 (ELISA

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Keywords HDM2 • Inhibitors • MDM2 • Protein-protein interactions. 1 Introduction. 1.1 The p53 Tumor Suppressor and Its Primary Cellular. Inhibitor MDM2 Protein. Tumor suppressor p53 is a transcriptional factor that plays a pivotal role in the r

p53 protein overexpression in nasopharyngeal carcinoma in Indonesian patients. A.N.Kurniavan* ... Indonesian NPC patients and correlated it with two NPC histological classifications. p53 protein over-expression were respectively found in 100% ..... L

Feb 6, 1997 - apoptosis if damage is too high. Loss of p53 function conditions: mice lacking the p53 gene develop and grow appears to be an important step ...

Oct 15, 1993 - accumulation make the /;5.?tumor suppressor gene an attractive ... been detected in dysplastic bronchial lesions (9-12); (c) missense ... nostic differences of one grade (i.e., mild versus moderate dysplasia) were ... human p53 protein

6. Gardjito, W 2002, 'Rational use of antibiotics in the management of sepsis' in PIT I Perhimpunan. Patobiologi Indonesia, Surabaya. Hanafiah, A 2002, Rancangan Percobaan Aplikasi dan. Teori, Pusat Penerbitan FKUI, p. 6. Hotckhiss, RS, Irene, E & Ka

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and Oliver,24 the concentrations of drugs found for BZs. Table 4. The concentrations of .... Gagajewski A, Murakami MM, Kloss J, et al. Measurement of chemical ...

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Mdm2 protein binds to p53 and inactivates it (40–42). The binding occurs right .... The induced. ARF protein then binds to Mdm2, thus preventing p53 ubiquitina-.